The aim of the project is modelling and calculation of dposition of aerosols in human lungs ranging from (premature) neonate till adult.

Deposition of aerosols is governed by:

1) impaction (larger particles can not follow a curved pipe and impact on the wall due to their mass).

2) sedimentation (gravitational force)

3) Brownian movements of particles

4) electrostatic forces

5) other effects like: hydrofobic/hydrophylic, thermic gradients, shape of particel (spherical or not)

A lot of medication for pulmonary diseases are given as an aerosol since the drug targets directly the place of interest and systemic (=whole body) effects can be avoided. It is known from literature that the amount of drug which deposits in the lung is very low (reaching from 20% for adults till 2% for young children).

A target is to study how lungdeposition of medication can be increased (especially for young children).